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Research ArticleArticle
Open Access

Five and Ten Year Follow-up on Intradiscal Ozone Injection for Disc Herniation

Josip Buric, Luca Rigobello and David Hooper
International Journal of Spine Surgery January 2014, 8 17; DOI: https://doi.org/10.14444/1017
Josip Buric
1Villa Torri Hospital, Bologna, Italy
MD
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Luca Rigobello
2Department for Neurosurgery University of Padua, Padova, Italy
MD
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David Hooper
3Minimus Spine, Inc. Austin, TX
PhD
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Abstract

Background Disc herniation is the most common cause for spinal surgery and many clinicians employ epidural steroid injections with limited success. Intradiscal injection of ozone gas has been used as an alternative to epidural steroids and surgical discectomy. Early results are positive but long-term data are limited.

Methods One hundred and eight patients with confirmed contiguous disc herniation were treated with intradiscal injection of ozone in 2002-2003. One-hundred seven patients were available for telephone follow-up at 5 years. Sixty patients were available for a similar telephone follow-up at ten years. Patients were asked to describe their clinical outcome since the injection. Surgical events were documented. MRI images were reviewed to assess the reduction in disc herniation at six months.

Results MRI films demonstrated a consistent reduction in the size of the disc herniation. Seventy-nine percent of patients had a reduction in herniation volume and the average reduction was 56%. There were 19 patients that ultimately had surgery and 12 of them occurred in the first six months after injection. One of these 12 was due to surgery at another level. Two surgeries involved an interspinous spacer indicated by stenosis or DDD. All other surgeries were discectomies. Of the patients that avoided surgery 82% were improved at 5 years and 88% were improved at 10 years. Other than subsequent surgeries, no spine-related complications were experienced.

Conclusions/Level of Evidence We conclude that ozone is safe and effective in approximately 75% of patients with disc herniation and the benefit is maintained through ten years. This is a retrospective review and randomized trials are needed.

Clinical Relevance Intradiscal ozone injection may enable patients to address their pain without multiple epidural injections and surgery. The benefit of ozone is durable and does not preclude future surgical options. The risk reward profile for this treatment is favorable.

  • Copyright © 2014 ISASS - International Society for the Advancement of Spine Surgery

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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1 Jan 2014
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Five and Ten Year Follow-up on Intradiscal Ozone Injection for Disc Herniation
Josip Buric, Luca Rigobello, David Hooper
International Journal of Spine Surgery Jan 2014, 8 17; DOI: 10.14444/1017

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Five and Ten Year Follow-up on Intradiscal Ozone Injection for Disc Herniation
Josip Buric, Luca Rigobello, David Hooper
International Journal of Spine Surgery Jan 2014, 8 17; DOI: 10.14444/1017
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