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Research ArticleArticle
Open Access

Prospective Analysis of a New Bone Graft in Lumbar Interbody Fusion: Results of a 2- Year Prospective Clinical and Radiological Study

Philippe Lauweryns and Yannic Raskin
International Journal of Spine Surgery January 2015, 9 2; DOI: https://doi.org/10.14444/2002
Philippe Lauweryns
Orthopaedic Surgery, Sint-Trudo ZiekenHuis, Sint- Truiden, Belgium
MD, PhD
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Yannic Raskin
Orthopaedic Surgery, Sint-Trudo ZiekenHuis, Sint- Truiden, Belgium
MD
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  • Article
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Article Figures & Data

Figures

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  • Figure 1
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    Figure 1

    PLIF Cages/Study Model.

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    Figure 2

    Intra-cage zones for assessing fusion.

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    Figure 3

    Patient Outcomes.

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    Figure 4

    Radiology analysis/methodology; 40 patients, 45 levels.

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    Figure 5

    Occurrence by zone.

Tables

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    Table 1

    Patient demographics.

    Patient Demographics
    No. of Patients (levels)40 (45)
    Mean (range) age in years52 (28-69)
    Sex (M/F)15/25
    BMI
    Underweight (<18.5)n = 0
    Normal Range (18.5-25)n = 16
    Overweight (25-30)n = 16
    Obese (>30)n = 8
    Tobacco Use (%)11 (27.5 %)
    Diabetes (%)5 (12.5%)
    Mean (range) follow up period24 months
    Mean (range) Length of Stay5.9 days (5-8)
    Mean (range) Intra-operative blood loss173cc (100-300)
    Mean (range) Operation Time158mins (105-300)
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    Table 2

    Levels treated.

    No. of levelsNo of Patients (%)LevelNumber(%)
    One24 (60%)L2/30 (0%)
    Two14 (35%)L3/43 (7%)
    Three1 (2.5%)L4/525 (56%)
    Four1 (2.5%)L5/S117 (38%)
    Total40 (100%)Total45 (100%)
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    Table 3

    Presence of bridging bone intra-cage (N = 45 levels).

    6 months*12 months24 months
    AutoP-15P-value**AutoP-15P-value**AutoP-15P-value**
    Anterior34.09 %70.45%< .0157.78%88.89%< .0171.11%88.89%n.s.
    Mid43.18 %86.36%< .0173.33%95.56%< .0180.00%93.33%n.s.
    Posterior45.45%68.18%n.s.73.33%82.22%n.s.84.44%86.67%n.s.
    Any59.09%97.73%< .0182.22%97.78%< .0193.33%95.56%n.s.
    Any sign rank test1.23±1.202.25±.78< .012.04±1.142.67±.60< .01
    • ↵* N= 44 (1 case missing CT)

    • ↵** McNemar test

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    Table 4

    Patient outcomes.

    N = 40 patientsPreoperative3 months6 months12 months24 months% gain 2Yr
    VAS back pain662342253729 %
    VAS left leg492525232227 %
    VAS right leg381916181622 %
    ODI463018302620 %
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    Table 5

    Reported occurrence of bone posterior to interbody cages.

    Joseph & Rampersaud22Haid, et al26Lauweryns & Raskin
    rhBMP-2AutograftrhBMP-2AutograftABM/P-15Autograft
    n = 23n = 10n = 32n = 31n = 45n = 45
    21%8%75%13%48%14%
    Minimal23%8%
    Mild22%6%
    Moderate3%0%
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International Journal of Spine Surgery
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1 Jan 2015
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Prospective Analysis of a New Bone Graft in Lumbar Interbody Fusion: Results of a 2- Year Prospective Clinical and Radiological Study
Philippe Lauweryns, Yannic Raskin
International Journal of Spine Surgery Jan 2015, 9 2; DOI: 10.14444/2002

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Prospective Analysis of a New Bone Graft in Lumbar Interbody Fusion: Results of a 2- Year Prospective Clinical and Radiological Study
Philippe Lauweryns, Yannic Raskin
International Journal of Spine Surgery Jan 2015, 9 2; DOI: 10.14444/2002
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  • Three- and 4-Level Lumbar Arthrodesis Using Adjunctive Pulsed Electromagnetic Field Stimulation: A Multicenter Retrospective Evaluation of Fusion Rates and a Review of the Literature
  • ISASS Recommendations and Coverage Criteria for Bone Graft Substitutes used in Spinal Surgery
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Keywords

  • PLIF
  • lumbar fusion
  • bone graft alternative
  • peptide
  • ABM/P-15
  • P-15

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