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Research ArticleArticles

Fine grained osseointegrative coating improves biocompatibility of PEEK in heterotopic sheep model

Caroline M.F. Meers, Gino B.M. Verleye, Dirk Smeets, Hadewych Y.R. Van Hauwermeiren, Dirk Loeckx, Karel Willems, Vincent G.M.G.G.B. Siau and Philippe J.M.E. Lauweryns
International Journal of Spine Surgery January 2015, 9 35; DOI: https://doi.org/10.14444/2035
Caroline M.F. Meers
1Medanex Clinic, Diest, Belgium
DVM, PhD
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Gino B.M. Verleye
2Social Sciences Department, Ghent University, Ghent, Belgium
PhD
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Dirk Smeets
3IcoMetrix, Leuven, Belgium
PhD
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Hadewych Y.R. Van Hauwermeiren
1Medanex Clinic, Diest, Belgium
DVM, MLAS
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Dirk Loeckx
3IcoMetrix, Leuven, Belgium
PhD
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Karel Willems
4Department of Orthopaedic Surgery, AZ Delta, Roeselare, Belgium
MD
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Vincent G.M.G.G.B. Siau
5Orthobion GmbH Konstanz, Germany
MSc
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Philippe J.M.E. Lauweryns
6Department of Morphology, Hasselt University, Diepenbeek, Belgium
MD, PhD
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Article Figures & Data

Figures

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  • Fig. 1
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    Fig. 1

    Detection of the cylindrical dowel with original image (a), dowel probability map (b), Hough transformed image (c), and line fitting through the maxima of the Hough images (d).

  • Fig. 2
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    Fig. 2

    Images sampled at 30 voxels from the implant surface and stratified for visualization.

  • Fig. 3
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    Fig. 3

    Volumes of interest (blue) around the dowel (orange). In this figure, 24 VOIs are drawn (3 times 8). In our analysis we use 60 VOIs (5 times 12).

  • Fig. 4
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    Fig. 4

    Representative slices for titanium, (A), CaP, (B) and control (C).

  • Fig. 5
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    Fig. 5

    Time * Treatment statistics for BIC in the 6 to 26 weeks period. No significant differences were observed (p = 0.24100).

  • Fig. 6
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    Fig. 6

    Time * Treatment statistics for BIC in the 6 to 12 weeks period. BIC was significantly higher in the titanim group compared to the control.

  • Fig. 7
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    Fig. 7

    Time * Treatment statistics for BV/TV in the 6 to 26 weeks period. No significant differences were observed (p = 0.28789).

  • Fig. 8
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    Fig. 8

    Time * Treatment statistics for BIC in the 6 to 12 weeks period. BIC was significantly higher in the titanium group compared to the control.

  • Fig. 9
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    Fig. 9

    Correlation between BIC and BV/TV.

  • Fig. 10
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    Fig. 10

    Histological sections stained with Stevenel's blue and Von Gieson's picrofuchsin of (a) titanium with direct bone implant contact, (b) CaP with direct bone implant contact (c) Control presence of cartilage tissue and fibrotic layers between the dowel and the surrounding bone tissue.

Tables

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    Table 1

    Experimental set-up.

    Study Design (Animals n = 6)
    Follow-up 6 weeks12 weeks26 weeks
    Animals n = 2n = 2n = 2
    Implants n = 16n = 16n = 16
    LocationTibia n = 8Femur n = 8Tibia n = 8Femur n = 8Tibia n = 8Femur n = 8
    CoatingControl n =4
    Titanium n = 6
    CaP n = 6
    Control n =4
    Titanium n = 6
    CaP n = 6
    Control n =4
    Titanium n = 6
    CaP n = 6
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    Table 2

    Descriptive information on bone implant contact.

    BIC6 weeks12 weeks26 weeks
    TitaniumN666
    Mean22.78365.04067,.902
    Std.Err.7.2287.2287.228
    CaPN666
    Mean45.17061.66363.184
    Std.Err.7.2287.2287.228
    ControlN444
    Mean28.43741.67053.793
    Std.Err.8.8528.8528.852
    • View popup
    Table 3

    Descriptive information on bone volume/tissue volume.

    BV/TV6 weeks12 weeks26 weeks
    TitaniumN666
    Mean21.21745.23647.036
    Std.Err.6.5386.5386.538
    CaPN666
    Mean37.02742.53349.995
    Std.Err.6.5386.5386.538
    ControlN444
    Mean36.88929.31540.498
    Std.Err.8.0078.0078.007
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International Journal of Spine Surgery
Vol. 9
1 Jan 2015
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Fine grained osseointegrative coating improves biocompatibility of PEEK in heterotopic sheep model
Caroline M.F. Meers, Gino B.M. Verleye, Dirk Smeets, Hadewych Y.R. Van Hauwermeiren, Dirk Loeckx, Karel Willems, Vincent G.M.G.G.B. Siau, Philippe J.M.E. Lauweryns
International Journal of Spine Surgery Jan 2015, 9 35; DOI: 10.14444/2035

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Fine grained osseointegrative coating improves biocompatibility of PEEK in heterotopic sheep model
Caroline M.F. Meers, Gino B.M. Verleye, Dirk Smeets, Hadewych Y.R. Van Hauwermeiren, Dirk Loeckx, Karel Willems, Vincent G.M.G.G.B. Siau, Philippe J.M.E. Lauweryns
International Journal of Spine Surgery Jan 2015, 9 35; DOI: 10.14444/2035
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Keywords

  • titanium
  • Bone ingrowth
  • Polyetheretherketone
  • spinal surgery
  • Nanotopography
  • In vivo test

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