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Research ArticleLumbar Spine

How Much Blood Loss Is Appropriate for a 2- to 3-Level Posterior Lumbar Fusion?

Jeffrey W. Chen, Hani Chanbour, Steven G. Roth, Byron F. Stephens, Amir M. Abtahi and Scott L. Zuckerman
International Journal of Spine Surgery February 2023, 8423; DOI: https://doi.org/10.14444/8423
Jeffrey W. Chen
1 Vanderbilt University School of Medicine, Nashville, TN, USA
BA
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  • For correspondence: scott.zuckerman@vumc.org
Hani Chanbour
2 Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA
MD
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Steven G. Roth
2 Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA
MD
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Byron F. Stephens
2 Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA
3 Department of Orthopedic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA
MD, MSCI
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Amir M. Abtahi
2 Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA
3 Department of Orthopedic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA
MD
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Scott L. Zuckerman
1 Vanderbilt University School of Medicine, Nashville, TN, USA
3 Department of Orthopedic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA
MD, MPH
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  • Figure 1
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    Figure 1

    Histogram showing the distribution of estimated blood loss (EBL) in milliliters in patients with 2-level (A) and 3-level (B) posterolateral lumbar fusion, with and without interbody fusion.

  • Figure 2
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    Figure 2

    Receiver operating characteristic curves of estimated blood loss (EBL) vs length of stay in 2-level (A) and 3-level (B) posterolateral lumbar fusion. AUC, area under the curve; Se, sensitivity; Sp, specificity.

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    Figure 3

    Comparison of 25th centile and Youden’s Index of patients with prolonged length of stay (LOS) in 2-level (A) and 3-level (B) posterolateral lumbar fusion. The red vertical lines indicate the calculated Youden’s Index. The purple lines show the 25th centile of patients with prolonged LOS. Estimated blood loss is given in milliliters. ROC, receiver operating characteristic curve.

Tables

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    Table 1

    Demographic characteristics of patients receiving 2- and 3-level posterolateral lumbar fusion.

    Variables2-Level Fusion (N = 557)3-Level Fusion (N = 287)
    Age, mean ± SD61.74 ± 12.0563.71 ± 11.57
    Gender: men, n (%)277 (50.0%)128 (44.9%)
    Race: White, n (%)482 (87.2%)264 (93.0%)
    Body mass index, mean ± SD31.23 ± 6.6830.67 ± 6.44
    Comorbidities, n (%)
     1 or 2 Comorbidities319 (57.3%)165 (57.5%)
     >2 Comorbidities153 (27.5%)87 (30.3%)
     Coronary artery disease99 (23.6%)53 (22.9%)
     Hypertension350 (62.8%)193 (67.2%)
     Congestive heart failure17 (3.1%)10 (3.5%)
     Chronic obstructive pulmonary disease31 (5.6%)10 (3.5%)
     Osteoporosis17 (4.1%)14 (6.1%)
     Diabetes142 (25.5%)72 (25.1%)
    Active smoker, n (%)88 (15.8%)51 (17.8%)
    Preoperative anticoagulation/antiplatelet usage, n (%)13 (3.1%)8 (3.5%)
    Insurance, n (%)
     Private237 (42.5%)95 (33.1%)
     Medicare/Medicaid/Tenncare265 (47.6%)171 (59.6%)
     Veterans Affairs/Government (includes Tricare)38 (6.8%)15 (5.2%)
     Uninsured/not available7 (1.3%)3 (1.0%)
    Currently employed, n (%)191 (34.4%)67 (23.3%)
    Intend to return to work, n (%)183 (95.8%)59 (89.4%)
    Preoperative ambulation, n (%)
     With assistance179 (32.3%)96 (33.4%)
     Independent371 (66.8%)189 (65.9%)
     Wheelchair bound5 (0.9%)2 (0.7%)
    Duration of symptoms, n (%)
     <3 mo33 (7.6%)15 (6.5%)
     3–12 mo141 (32.4%)67 (29.1%)
     >12 mo261 (60.0%)148 (64.3%)
    Diagnosis, n (%)
     Stenosis132 (24.0%)66 (23.6%)
     Herniated disc11 (2.0%)10 (3.6%)
     Fracture29 (5.3%)14 (5.0%)
     Deformity/scoliosis43 (7.8%)60 (21.4%)
     Spondylolisthesis280 (51.0%)97 (34.6%)
     Pseudarthrosis30 (5.5%)22 (7.9%)
     Other22 (4.0%)11 (4.0%)
    Revision, n (%)214 (38.4%)135 (47.0%)
    Reason for revision, n (%)
     Adjacent segment disease68 (38.4%)43 (38.4%)
     Pseudarthrosis/instrumentation failure34 (19.2%)30 (26.8%)
     Same level recurrent stenosis53 (29.9%)26 (23.2%)
     Same level recurrent disc herniation16 (9.0%)6 (5.4%)
     Other6 (3.4%)7 (6.3%)
    • View popup
    Table 2

    Operative and perioperative variables of patients receiving 2- and 3-level posterolateral lumbar fusion.

    Variables2-Level Fusion (N = 557)3-Level Fusion (N = 287)
    Estimated blood loss (mL), mean ± SD583.09 ± 447.54790.32 ± 682.26
    Operative time (min), mean ± SD240.82 ± 68.47272.82 ± 75.74
    Interbody placement, n (%)178 (32.0%)70 (24.4%)
    Length of stay (d), mean ± SD3.44 ± 1.824.46 ± 2.67
    Discharged, n (%)
     Home443 (85.0%)202 (74.5%)
     In-patient rehabilitation facility48 (9.2%)46 (17.0%)
     Skilled nursing facility30 (5.8%)23 (8.5%)
    • View popup
    Table 3

    Medical/surgical complications within 30 d after lumbar spine surgery.

    Variables, n (%)2-Level Fusion (N = 557)3-Level Fusion (N = 287)
    Complication43 (7.7%)33 (11.5%)
    Urinary tract infection26 (4.7%)15 (5.2%)
    Hematoma0 (0.0%)2 (0.7%)
    Neurological deficit5 (0.9%)4 (1.4%)
    Pneumonia2 (0.4%)1 (0.3%)
    Deep vein thrombosis2 (0.4%)2 (0.7%)
    SSI14 (2.5%)12 (4.2%)
    SSI treatment
     Oral antibiotics6 (42.9%)3 (25.0%)
     IV antibiotics2 (14.3%)2 (16.7%)
     Surgical incision and drainage with IV antibiotics5 (35.7%)6 (50.0%)
    Readmission38 (8.9%)22 (9.4%)
    Reoperation12 (2.9%)14 (6.1%)
    Reason for reoperation
     Revised implants2 (16.7%)2 (14.3%)
     SSI/wound dehiscence5 (41.7%)6 (42.9%)
     Other5 (41.7%)6 (42.9%)
    • Abbreviations: IV, intravenous; SSI, surgical site infection.

    • View popup
    Table 4

    Receiver operating characteristic curve analysis of 2- and 3-level posterolateral lumbar fusion with patient-reported outcomes.

    OutcomesEstimated Blood Loss, mLArea Under the Curve (95% CI) P Value
    2-Level Fusion (N = 557)
     Length of stay POD23750.64 (0.58–0.7)<0.001
     Complication (30 d)637.50.5 (0.38–0.61)<0.001
     MCID ODI287.50.54 (0.48–0.6)<0.001
     MCID NRS back9750.53 (0.46–0.59)<0.001
     MCID NRS leg9750.51 (0.44–0.57)<0.001
    3-Level Fusion (N = 287)
     Length of stay POD26750.63 (0.54–0.73)0.012
     Complication (30 d)5380.63 (0.51–0.76)<0.001
     MCID ODI6750.52 (0.44–0.6)<0.001
     MCID NRS back512.50.57 (0.49–0.65)<0.001
     MCID NRS leg3750.46 (0.37–0.56)<0.001
    • Abbreviations: MCID, minimal clinically important difference; NRS, Numerical Rating Scale; ODI, Oswestry Disability Index; POD2, postoperative day 2.

    • View popup
    Table 5

    Patient-reported outcomes of 2- and 3-level posterolateral lumbar fusion.

    OutcomesPreoperative3 moMinimal Clinically Important Difference 30% Reduction at 3 mo P Value,
    3 mo to Preoperative
    2-Level Fusion (N = 557)
     NRS back6.97 ± 2.303.94 ± 2.72303 (62.3%)<0.001
     NRS leg6.34 ± 2.863.06 ± 3.21294 (64.8%)<0.001
     ODI48.48 ± 14.2132.27 ± 17.83269 (54.0%)<0.001
    3-Level Fusion (N = 287)
     NRS back7.14 ± 2.193.81 ± 2.58172 (66.7%)<0.001
     NRS leg6.60 ± 2.972.58 ± 2.98181 (74.2%)<0.001
     ODI48.63 ± 13.9034.18 ± 16.44131 (50.0%)<0.001
    • Abbreviations: NRS, Numerical Rating Scale; ODI, Oswestry Disability Index.

    • Note: Data presented as mean ± SD for continuous variables and n (%) for categorical variables.

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International Journal of Spine Surgery: 19 (S2)
International Journal of Spine Surgery
Vol. 19, Issue S2
1 Apr 2025
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How Much Blood Loss Is Appropriate for a 2- to 3-Level Posterior Lumbar Fusion?
Jeffrey W. Chen, Hani Chanbour, Steven G. Roth, Byron F. Stephens, Amir M. Abtahi, Scott L. Zuckerman
International Journal of Spine Surgery Feb 2023, 8423; DOI: 10.14444/8423

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How Much Blood Loss Is Appropriate for a 2- to 3-Level Posterior Lumbar Fusion?
Jeffrey W. Chen, Hani Chanbour, Steven G. Roth, Byron F. Stephens, Amir M. Abtahi, Scott L. Zuckerman
International Journal of Spine Surgery Feb 2023, 8423; DOI: 10.14444/8423
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