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Research ArticleEndoscopic Minimally Invasive Surgery

Efficacy of Epidural Steroid in Controlling Pain After Unilateral Biportal Endoscopic Discectomy for Single-Level Lumbar Disc Herniation: A Randomized, Double-Blind, Placebo-Controlled Trial

Rattalerk Arunakul, Thanapat Boonraksa, Punnawit Pinitchanon, Koopong Siribumrungwong, Thongchai Suntharapa and Waroot Pholsawatchai
International Journal of Spine Surgery October 2024, 8655; DOI: https://doi.org/10.14444/8655
Rattalerk Arunakul
1 Department of Orthopedics, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand
MD
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Thanapat Boonraksa
1 Department of Orthopedics, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand
MD
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Punnawit Pinitchanon
1 Department of Orthopedics, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand
MD
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Koopong Siribumrungwong
2 Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, Thailand
MD
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Thongchai Suntharapa
1 Department of Orthopedics, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand
MD
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Waroot Pholsawatchai
2 Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, Thailand
MD
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  • For correspondence: warootmountaindew@gmail.com
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  • Figure 1
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    Figure 1

    Consolidated Standards of Reporting Trials (CONSORT) flow diagram. ES, epidural steroid; UBE-D, unilateral biportal endoscopic discectomy.

  • Figure 2
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    Figure 2

    The 12-gauge, 50-mm needle was inserted through the patient’s skin into the interlaminar space near the traversing nerve root. Subsequently, the epidural catheter was threaded through the needle, positioning its tip proximate to the traversing nerve root. Following the closure of the wound, either the epidural steroid or placebo was injected for up to 2 hours postoperatively.

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    Figure 3

    Mean values of VAS of back pain after unilateral biportal endoscopic discectomy. VAS, visual analog scale; ES, epidural steroid.

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    Figure 4

    Mean values of VAS of leg pain after unilateral biportal endoscopic discectomy. VAS, visual analog scale; ES, epidural steroid.

  • Figure 5
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    Figure 5

    Mean values of ODI after unilateral biportal endoscopic discectomy. ODI, Oswestry Disability Index; ES, epidural steroid.

Tables

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    Table 1

    Comparison of demographic data between the 2 study groups.

    DataES (n = 30)Placebo (n = 30) P
    Sex, n (%)
     Men13 (43.33)10 (33.33)0.59
     Women17 (56.67)20 (66.67)
    Age, y, mean (SD)49 (15)53 (12)0.27
    Weight, kg, mean (SD)68 (10)65 (10)0.27
    Height, cm, mean (SD)164 (9)161 (8)0.14
    BMI, mean (SD)25.35 (3.36)25.20 (3.22)0.86
    Surgical level, n (%)
     L3/L44 (13.33)2 (6.67)0.561
     L4/L517 (56.67)16 (53.3)
     L5/S19 (30)12 (40)
    Operative time, min, mean (SD)116 (27)112 (34)0.63
    Preoperative CRP, mean (SD)2.8 (3.2)3 (8)0.89
    Preoperative score, mean (SD)
     VAS back pain6.4 (3.3)5 (4.1)0.15
     VAS leg pain7.7 (2.3)7.8 (2.5)0.83
     ODI54 (14)60 (17)0.12
    • Abbreviations: BMI, body mass index; CRP, C-reactive protein; ES, epidural steroid; ODI, Oswestry Disability Index; VAS, visual analog score.

    • View popup
    Table 2

    Comparison of VAS and ODI scores data between the 2 groups.

    OutcomesES (n = 30)Placebo (n = 30) diff P
    VAS back pain score, mean (SD)
     6 h postoperative2.7 (1.82)2.7 (1.62)0 (−0.8 to 0.7)0.93
     12 h postoperative1.96 (1.65)1.8 (0.15)0.16 (−0.6 to 0.9)0.67
     24 h postoperative1.7 (1.23)1.6 (1.16)0.1 (−0.7 to 0.9)0.79
     3 wk postoperative1.26 (1.77)1 (1.53)0.26 (−0.5 to 1.0)0.5
     6 wk postoperative0.43 (1.10)0.53 (1.54)−0.1 (−0.9 to 0.7)0.8
     3 mo postoperative0.86 (2.11)0.6 (1.22)0.26 (−0.5 to 1.0)0.5
     6 mo postoperative0.8 (1.64)0.6 (1.24)0.2 (−0.5 to 0.9)0.61
    VAS leg pain score, mean (SD)
     6 h postoperative1.56 (1.65)1.16 (1.59)0.4 (−1.0 to 1.9)0.6
     12 h postoperative1.16 (1.36)1.03 (1.40)0.13 (−1.4 to 1.6)0.86
     24 h postoperative0.96 (1.03)1.13 (1.27)−0.16 (−1.7 to 1.3)0.83
     3 wk postoperative1.57 (2.40)1.43 (1.88)0.14 (−0.8 to 1.1)0.78
     6 wk postoperative1.16 (2.67)1.03 (1.08)0.13 (−1.4 to 1.6)0.86
     3 mo postoperative0.93 (2.31)0.76 (1.56)0.17 (−1.3 to 1.7)0.83
     6 mo postoperative1.03 (2.26)0.76 (2.02)0.27 (−1.2 to 1.8)0.73
    ODI score, mean (SD)
     3 wk postoperative26.46 (16.81)28.86 (15.56)−2.4 (−9 to 4.1)0.47
     6 wk postoperative11.33 (11.1)11.46 (10.92)−0.13 (−6.7 to 6.4)0.97
     3 mo postoperative7.1 (13.5)7.6 (9.28)−0.5 (−7.1 to 6.0)0.87
     6 mo postoperative6.13 (11.67)7.2 (12.86)−1.1 (−7.6 to 5.5)0.75
    • Abbreviations: ES, epidural steroid; ODI, Oswestry Disability Index; VAS, visual analog scale.

    • View popup
    Table 3

    Comparison of outcomes and complications between the 2 groups.

    OutcomesES (n = 30)Placebo (n = 30)     P
    First 24 h morphine consumption, mg, mean (SD)1.3 (2.32)1.2 (1.86)0.85
    Postoperative length of hospital stays, d, mean (SD)1.53 (0.56)1.4 (0.56)0.36
    24 h postoperative CRP, mg/L, mean (SD)7.824 (7.03)7.25 (9.9)0.79
    3 wk postoperative CRP, mg/L, mean (SD)3.715 (6.34)5.07 (10.57)0.54
    Postoperative complication for 6 mo00-
    Steroid-related complication for 6 mo00-
    • Abbreviations: CRP, C-reactive protein; ES, epidural steroid.

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International Journal of Spine Surgery: 19 (S2)
International Journal of Spine Surgery
Vol. 19, Issue S2
1 Apr 2025
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Efficacy of Epidural Steroid in Controlling Pain After Unilateral Biportal Endoscopic Discectomy for Single-Level Lumbar Disc Herniation: A Randomized, Double-Blind, Placebo-Controlled Trial
Rattalerk Arunakul, Thanapat Boonraksa, Punnawit Pinitchanon, Koopong Siribumrungwong, Thongchai Suntharapa, Waroot Pholsawatchai
International Journal of Spine Surgery Oct 2024, 8655; DOI: 10.14444/8655

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Efficacy of Epidural Steroid in Controlling Pain After Unilateral Biportal Endoscopic Discectomy for Single-Level Lumbar Disc Herniation: A Randomized, Double-Blind, Placebo-Controlled Trial
Rattalerk Arunakul, Thanapat Boonraksa, Punnawit Pinitchanon, Koopong Siribumrungwong, Thongchai Suntharapa, Waroot Pholsawatchai
International Journal of Spine Surgery Oct 2024, 8655; DOI: 10.14444/8655
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Keywords

  • lumbar disc herniation
  • epidural steroid
  • unilateral biportal endoscopic (UBE)
  • discectomy

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