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Research ArticleLumbar Spine

Risk of Cancer Following Lumbar Fusion Surgery With Recombinant Human Bone Morphogenic Protein-2 (rhBMP-2): An Analysis Using a Commercially Insured Patient Population

GREGORY S. COOPER and TZUYUNG DOUG KOU
International Journal of Spine Surgery April 2018, 12 (2) 260-268; DOI: https://doi.org/10.14444/50323
GREGORY S. COOPER
1University Hospitals Cleveland Medical Center, Division of Gastroenterology, Cleveland, Ohio
2Case Western Reserve University, Case Comprehensive Cancer Center, Cleveland, Ohio
MD
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TZUYUNG DOUG KOU
1University Hospitals Cleveland Medical Center, Division of Gastroenterology, Cleveland, Ohio
PhD
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    Figure

    Kaplan-Meier plot of malignant neoplasia risk in recombinant human bone morphogenic protein (rhBMP)-treated and untreated patients. Through a follow-up period of up to 8 years, patients receiving rhBMP were at similar risk to receive a cancer diagnosis as untreated patients (P = .2687 by log-rank test).

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International Journal of Spine Surgery
Vol. 12, Issue 2
1 Apr 2018
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Risk of Cancer Following Lumbar Fusion Surgery With Recombinant Human Bone Morphogenic Protein-2 (rhBMP-2): An Analysis Using a Commercially Insured Patient Population
GREGORY S. COOPER, TZUYUNG DOUG KOU
International Journal of Spine Surgery Apr 2018, 12 (2) 260-268; DOI: 10.14444/50323

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Risk of Cancer Following Lumbar Fusion Surgery With Recombinant Human Bone Morphogenic Protein-2 (rhBMP-2): An Analysis Using a Commercially Insured Patient Population
GREGORY S. COOPER, TZUYUNG DOUG KOU
International Journal of Spine Surgery Apr 2018, 12 (2) 260-268; DOI: 10.14444/50323
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More in this TOC Section

  • Recovery Trajectories After Lumbar Fusion Stratified by Baseline Patient-Reported Outcomes Measurement Information System Physical Function Disability Levels
  • Safety and Viability of Anterior Lumbar Interbody Fusion in Complex Revision Lumbar Spine Surgeries: Insights From a Case Series of 135 Patients on Transforaminal Lumbar Interbody Fusion/Posterior Lumbar Interbody Fusion Cage Removal
  • Effects of Body Mass Index on Spondylolisthesis Surgery and Associated Patient-Reported Outcomes: A Retrospective Review
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Keywords

  • human BMP-2 protein
  • spinal fusion
  • carcinogenesis
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