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Research ArticleLumbar Spine

Improved Surgical Correction Relative to Patient-Specific Ideal Spinopelvic Alignment Reduces Pelvic Nonresponse for Severely Malaligned Adult Spinal Deformity Patients

Peter G. Passias, Cole Bortz, Haddy Alas, Kevin Moattari, Avery Brown, Katherine E. Pierce, Jordan Manning, Ethan W. Ayres, Christopher Varlotta, Erik Wang, Tyler K. Williamson, Bailey Imbo, Rachel Joujon-Roche, Peter Tretiakov, Oscar Krol, Burhan Janjua, Daniel Sciubba, Bassel G. Diebo, Themistocles Protopsaltis, Aaron J. Buckland, Frank J. Schwab, Renaud Lafage and Virginie Lafage
International Journal of Spine Surgery June 2022, 16 (3) 530-539; DOI: https://doi.org/10.14444/8254
Peter G. Passias
1 Department of Orthopedics, NYU Langone Orthopedic Hospital, New York, NY, USA
MD
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Cole Bortz
1 Department of Orthopedics, NYU Langone Orthopedic Hospital, New York, NY, USA
BA
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Haddy Alas
1 Department of Orthopedics, NYU Langone Orthopedic Hospital, New York, NY, USA
MD
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Kevin Moattari
1 Department of Orthopedics, NYU Langone Orthopedic Hospital, New York, NY, USA
BS
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Avery Brown
1 Department of Orthopedics, NYU Langone Orthopedic Hospital, New York, NY, USA
BS
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Katherine E. Pierce
1 Department of Orthopedics, NYU Langone Orthopedic Hospital, New York, NY, USA
BS
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Jordan Manning
1 Department of Orthopedics, NYU Langone Orthopedic Hospital, New York, NY, USA
BA
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Ethan W. Ayres
1 Department of Orthopedics, NYU Langone Orthopedic Hospital, New York, NY, USA
MD, MPH
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Christopher Varlotta
1 Department of Orthopedics, NYU Langone Orthopedic Hospital, New York, NY, USA
BS
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Erik Wang
1 Department of Orthopedics, NYU Langone Orthopedic Hospital, New York, NY, USA
BS
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Tyler K. Williamson
1 Department of Orthopedics, NYU Langone Orthopedic Hospital, New York, NY, USA
MS
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Bailey Imbo
1 Department of Orthopedics, NYU Langone Orthopedic Hospital, New York, NY, USA
BA
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Rachel Joujon-Roche
1 Department of Orthopedics, NYU Langone Orthopedic Hospital, New York, NY, USA
BS
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Peter Tretiakov
1 Department of Orthopedics, NYU Langone Orthopedic Hospital, New York, NY, USA
BS
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Oscar Krol
1 Department of Orthopedics, NYU Langone Orthopedic Hospital, New York, NY, USA
BA
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Burhan Janjua
1 Department of Orthopedics, NYU Langone Orthopedic Hospital, New York, NY, USA
MD
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Daniel Sciubba
2 Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
MD
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Bassel G. Diebo
3 Department of Orthopedic Surgery, SUNY Downstate, New York, NY, USA
MD
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Themistocles Protopsaltis
1 Department of Orthopedics, NYU Langone Orthopedic Hospital, New York, NY, USA
MD
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Aaron J. Buckland
1 Department of Orthopedics, NYU Langone Orthopedic Hospital, New York, NY, USA
MBBS, FRACS
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Frank J. Schwab
4 Department of Orthopedics, Hospital for Special Surgery, New York, NY, USA
MD
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Renaud Lafage
4 Department of Orthopedics, Hospital for Special Surgery, New York, NY, USA
MS
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Virginie Lafage
4 Department of Orthopedics, Hospital for Special Surgery, New York, NY, USA
PhD
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  • Figure 1
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    Figure 1

    Schematic of global, regional, and lower extremity alignment parameters assessed in this study. SVA, sagittal vertical axis; GSA, global sagittal angle; TK, T4 T12 thoracic kyphosis; LL, L1 S1 lumbar lordosis; PT, pelvic tilt; PI, pelvic incidence; SFA, sacrofemoral angle; KA, knee angle; AA, ankle angle; PS, pelvic shift.

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    Figure 2

    Rates of pelvic nonresponse compared across patients undercorrected relative to ideal age-specific postoperative alignment targets, patients matching ideal targets, and patients overcorrected relative to ideal targets for pelvic tilt (PT) (2a), pelvic incidence and lumbar lordosis (PI-LL) (2b), and sagittal vertical axis (SVA) (2c). These comparisons were conducted within groups of increasing baseline Scoliosis Research Society (SRS)-Schwab SVA modifier severity (0, +, and ++).

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    Figure 3

    Rates of pelvic nonresponse compared across patients undercorrected relative to ideal age-specific postoperative alignment targets, patients matching ideal targets, and patients overcorrected relative to ideal targets for pelvic tilt (PT) (3a), pelvic incidence and lumbar lordosis (PI-LL) (3b), and sagittal vertical axis (SVA) (3c). These comparisons were conducted within groups of increasing baseline Scoliosis Research Society (SRS)-Schwab PI-LL modifier severity (0, +, and ++).

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    Figure 4

    Rates of pelvic nonresponse compared across patients undercorrected relative to ideal age-specific postoperative alignment targets, patients matching ideal targets, and patients overcorrected relative to ideal targets for pelvic tilt (PT) (4a), pelvic incidence and lumbar lordosis (PI-LL) (4b), and sagittal vertical axis (SVA) (4c). These comparisons were conducted within groups of increasing baseline Scoliosis Research Society (SRS)-Schwab PT modifier severity (0, +, and ++).

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    Figure 5

    Case examples showing preoperative and 6 months postoperative standing lateral radiographs of a pelvic nonresponse (left) and a pelvic response patient (right).

Tables

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    Table 1

    Comparison of baseline demographics, surgical factors, sagittal alignment, and lower limb alignment between PNR and PR.

    Baseline MeasuresPatient Group P Value
    PNR
    (N = 29)
    PR
    (N = 29)
    Demographics
     Age (y)64.4 ± 9.863.1 ± 12.60.668
     Sex (% female)62.1%72.4%0.401
     Body mass index (kg/m2)27.0 ± 7.229.0 ± 6.70.302
    Surgical factors
     Fusion length (levels)10.8 ± 3.710.8 ± 4.30.974
     Any osteotomy (%)92.6%91.7%0.902
    Baseline sagittal alignment
     Pelvic tilt (°)29.5 ± 6.029.2 ± 5.40.820
     Mismatch between pelvic incidence and lumbar lordosis (°)29.5 ± 15.930.9 ± 11.80.699
     Sagittal vertical axis (mm)98.1 ± 56.8109.0 ± 50.30.448
     T4 T12 thoracic kyphosis (°)−39.0 ± 21.3−29.7 ± 19.90.095
     T1 spinopelvic inclination (°)3.0 ± 7.14.8 ± 6.30.312
    Baseline lower limb alignment
     Sacrofemoral angle (°)208.1 ± 8.2204.2 ± 6.50.065
     Knee angle (°)8.7 ± 8.013.7 ± 8.9 0.043
     Ankle angle (°)7.1 ± 3.98.8 ± 4.60.172
     Pelvic shift (mm)76.7 ± 44.992.6 ± 55.60.267
     Global sagittal angle (°)10.2 ± 5.312.3 ± 5.80.180
    • Note: Data presented as mean ± SD or %. Bolded values indicate statistical significance at P < 0.05.

    • PNR, pelvic nonresponders; PR, pelvic responders.

    • View popup
    Table 2

    Rates of pre- to postoperative improvement in SRS-Schwab modifiers compared between PNR and PR.

    Radiographic Modifier ImprovementPNRPR P Value
    Improved in SRS-Schwab pelvic tilt modifier0%100% <0.001
    Improved in SRS-Schwab pelvic incidence-lumbar lordosis modifier48.3%85.7% 0.003
    Improved in SRS-Schwab sagittal vertical axis modifier60.7%64.3%0.783
    • Note: Bolded values indicate statistical significance at P < 0.05.

    • PNR, pelvic nonresponders; PR, pelvic responders; SRS, Scoliosis Research Society.

    • View popup
    Table 3

    Comparison of postoperative sagittal alignment and lower limb alignment between PNR and PR.

    Radiographic ParameterPatient Group P Value
    PNR
    (N = 29)
    PR
    (N = 29)
    Postoperative sagittal alignment
     Pelvic tilt (°)30.2 ± 6.717.4 ± 8.4 <0.001
     Mismatch between pelvic incidence and lumbar lordosis (°)17.0 ± 12.02.9 ± 10.9 <0.001
     Sagittal vertical axis (mm)51.6 ± 42.337.0 ± 45.60.209
     T4 T12 thoracic kyphosis (°)−46.6 ± 13.1−40.7 ± 18.30.163
     T1 spinopelvic inclination (°)−3.0 ± 5.3−1.8 ± 5.60.427
    Postoperative lower limb alignment
     Sacrofemoral angle (°)203.14 ± 38.7198.6 ± 7.90.535
     Knee angle (°)2.2 ± 29.712.9 ± 34.60.227
     Ankle angle (°)8.5 ± 4.60.3 ± 36.10.240
     Pelvic shift (mm)52.6 ± 30.831.2 ± 35.6 0.021
     Global sagittal angle (°)9.4 ± 16.23.8 ± 4.30.096
    • Note: Data presented as mean ± SD. Bolded values indicate statistical significance at P < 0.05.

    • PNR, pelvic nonresponders; PR, pelvic responders.

    • View popup
    Table 4

    Comparison of pre- to postoperative changes in lower limb alignment, as well as rates of residual postoperative lower extremity compensation, between PNR and PR.

    Radiographic ParameterPatient Group P Value
    PNR
    (N = 29)
    PR
    (N = 29)
    Pre- to postoperative change in lower limb alignment
     Sacrofemoral angle (°)2.1 ± 5.8−5.3 ± 7.0 <0.001
     Pelvic shift (mm)−24.1 ± 37.3−63.7 ± 42.5 0.001
     Pelvic femoral angle (°)−1.4 ± 2.2−3.8 ± 3.0 0.002
     Global sagittal angle (°)−3.5 ± 4.8−8.8 ± 4.4 <0.001
    Rates of persistent postoperative lower extremity compensation
     Sacrofemoral angle68%25% 0.003
     Ankle flexion64%33% 0.032
     Pelvic shift28%4% 0.049
    • Note: Data presented as mean ± SD or %. Bolded values indicate statistical significance at P < 0.05.

    • PNR, pelvic nonresponders; PR, pelvic responders.

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Improved Surgical Correction Relative to Patient-Specific Ideal Spinopelvic Alignment Reduces Pelvic Nonresponse for Severely Malaligned Adult Spinal Deformity Patients
Peter G. Passias, Cole Bortz, Haddy Alas, Kevin Moattari, Avery Brown, Katherine E. Pierce, Jordan Manning, Ethan W. Ayres, Christopher Varlotta, Erik Wang, Tyler K. Williamson, Bailey Imbo, Rachel Joujon-Roche, Peter Tretiakov, Oscar Krol, Burhan Janjua, Daniel Sciubba, Bassel G. Diebo, Themistocles Protopsaltis, Aaron J. Buckland, Frank J. Schwab, Renaud Lafage, Virginie Lafage
International Journal of Spine Surgery Jun 2022, 16 (3) 530-539; DOI: 10.14444/8254

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Improved Surgical Correction Relative to Patient-Specific Ideal Spinopelvic Alignment Reduces Pelvic Nonresponse for Severely Malaligned Adult Spinal Deformity Patients
Peter G. Passias, Cole Bortz, Haddy Alas, Kevin Moattari, Avery Brown, Katherine E. Pierce, Jordan Manning, Ethan W. Ayres, Christopher Varlotta, Erik Wang, Tyler K. Williamson, Bailey Imbo, Rachel Joujon-Roche, Peter Tretiakov, Oscar Krol, Burhan Janjua, Daniel Sciubba, Bassel G. Diebo, Themistocles Protopsaltis, Aaron J. Buckland, Frank J. Schwab, Renaud Lafage, Virginie Lafage
International Journal of Spine Surgery Jun 2022, 16 (3) 530-539; DOI: 10.14444/8254
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Keywords

  • adult spinal deformity
  • SRS-Schwab modifiers
  • pelvic tilt
  • pelvic nonresponders
  • postoperative alignment targets

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