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Research ArticleLumbar Spine

Possible Correlation Between Kyphosis of Lumbar Osteoporosis Fractures and the Spinal Signal Intensity Ratio (SSIR)

Tarek Omar Pacha, Amir Ghasemi, Mohamed Omar, Tilman Graulich, Christian Krettek, Yoon Wai Weng and Stubig Timo
International Journal of Spine Surgery May 2021, 8069; DOI: https://doi.org/10.14444/8069
Tarek Omar Pacha
1Trauma Department, Hannover Medical School (MHH), Lower Saxony, Germany
MD
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Amir Ghasemi
2Center for Spinal studies and Surgery, Nottingham University Hospital, United Kingdom
MD
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Mohamed Omar
1Trauma Department, Hannover Medical School (MHH), Lower Saxony, Germany
MD
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Tilman Graulich
1Trauma Department, Hannover Medical School (MHH), Lower Saxony, Germany
MD
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Christian Krettek
1Trauma Department, Hannover Medical School (MHH), Lower Saxony, Germany
MD
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Yoon Wai Weng
2Center for Spinal studies and Surgery, Nottingham University Hospital, United Kingdom
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Stubig Timo
1Trauma Department, Hannover Medical School (MHH), Lower Saxony, Germany
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ABSTRACT

Background The aim of this study was to examine the correlation between the risk of increasing kyphosis as well as collapse of the osteoporotic vertebral body fractures and the intensity of the bone edema in magnetic resonance imaging (MRI) scans. Inclusion criteria included the following: age >18 years and osteoporotic vertebral body fracture grade I–IV according to OF classification. Exclusion criteria included the following: other pathological fractures due to primary tumors or metastasis, OF grade V fractures, and AO type B or C fractures.

Methods This was a retrospective study from pseudonymized data of a tertiary spine center. No additional imaging were performed. Measurements of bisegmental kyphosis angle of the fracture for involvement of both endplates and monosegmental angle for involvement of 1 endplate, as well as vertebral body height loss in initial radiographs and at follow-ups after 3 and 6 months have been performed. Also, the initial signal intensity of the vertebral body edema was measured using integrated tool of the DICOM viewer (Impax V6.5 Agfa, Brentford, UK) in addition to the signal intensity of the cerebrospinal fluid (CSF) as reference for T1, T2, and separate target illumination radar (STIR) sequences of the MRI scans. A quotient from the signal intensity of the vertebral body edema and the reference (CSF) has been generated. Patients have been divided to 4 groups according to the ratio (<1, 1–2, 2–3, >3) and compared in regards to the results of the degree of kyphosis and vertebral collapse at follow-ups and final examination. The statistical analysis was performed using linear regression using statistic software SPSS version 26.

Results and Conclusions Forty-four patients have been included: 9 males and 35 females with an average age of 71.5 years. The analysis showed a significant correlation between the increasing kyphosis at follow-ups and the quotient of the signal intensity for STIR and T2 weighing with P = .002 (SD ±2.664) for STIR and P = .001 (SD ±1.616) for T2 sequences. Furthermore, there was only a correlation between the intensity ratio and kyphosis for STIR weighting at last examination (P = .017; SD ±1.360). There was no correlation between the height loss and the signal intensity.

Level of Evidence Level 2

  • spine
  • osteoporotic fractures
  • methods
  • MRI

Footnotes

  • Disclosures and COI: The authors received no funding for this study and report no conflicts of interest. Drs Pacha and Ghasemi contributed equally to this article.

  • This manuscript is generously published free of charge by ISASS, the International Society for the Advancement of Spine Surgery. Copyright © 2021 ISASS
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International Journal of Spine Surgery
Vol. 19, Issue 3
1 Jun 2025
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Possible Correlation Between Kyphosis of Lumbar Osteoporosis Fractures and the Spinal Signal Intensity Ratio (SSIR)
Tarek Omar Pacha, Amir Ghasemi, Mohamed Omar, Tilman Graulich, Christian Krettek, Yoon Wai Weng, Stubig Timo
International Journal of Spine Surgery May 2021, 8069; DOI: 10.14444/8069

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Possible Correlation Between Kyphosis of Lumbar Osteoporosis Fractures and the Spinal Signal Intensity Ratio (SSIR)
Tarek Omar Pacha, Amir Ghasemi, Mohamed Omar, Tilman Graulich, Christian Krettek, Yoon Wai Weng, Stubig Timo
International Journal of Spine Surgery May 2021, 8069; DOI: 10.14444/8069
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