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Research ArticleComplications

Therapeutic Application of Fibrinogen in Spine Surgery: A Review Article

Bardia Barimani, Philippe Moisan, Carlos Santaguida and Michael Weber
International Journal of Spine Surgery May 2021, 8075; DOI: https://doi.org/10.14444/8075
Bardia Barimani
1Division of Orthopedic Surgery, McGill University, Montreal, Quebec, Canada
MBBS
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Philippe Moisan
1Division of Orthopedic Surgery, McGill University, Montreal, Quebec, Canada
MD, CM
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Carlos Santaguida
2Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
MD
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Michael Weber
3Department of Surgery, McGill University, Montreal, Quebec, Canada
4Montreal General Hospital, Montreal, Quebec, Canada
MD, PHD
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ABSTRACT

Background The aim of this review is to investigate current uses of fibrinogen as a tool to reduce operative and postoperative blood loss in different surgical fields especially orthopedic spine surgery. This is a systematic review.

Methods MEDLINE (via Ovid 1946 to June 1, 2020) and Embase (via Ovid 1947 to June 1, 2020) were searched using the keywords “fibrinogen”, “surgery”, and “spine” for relevant studies. The search strategy used text words and relevant indexing to identify articles discussing the use of fibrinogen to control surgical blood loss.

Results The original literature search yielded 407 articles from which 68 duplications were removed. Three hundred thirty-nine abstracts and titles were screened. Results were separated by surgical specialties.

Conclusions Multiple studies have looked at the role of fibrinogen for acute bleeding in the operative setting. The current evidence regarding the use of fibrinogen concentrate in spine surgery is promising but limited, even though this is a field with the potential for severe hemorrhage. Further trials are required to understand the utility of fibrinogen concentrate as a first-line therapy in spine surgery and to understand the importance of target fibrinogen levels and subsequent dosing and administration to allow recommendations to be made in this field.

  • fibrinogen
  • spine surgery
  • hemorrhage
  • hemostasis

Footnotes

  • Disclosures and COI: The authors received no funding for this study and report no conflicts of interest.

  • This manuscript is generously published free of charge by ISASS, the International Society for the Advancement of Spine Surgery. Copyright © 2021 ISASS
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International Journal of Spine Surgery: 19 (S2)
International Journal of Spine Surgery
Vol. 19, Issue S2
1 Apr 2025
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Therapeutic Application of Fibrinogen in Spine Surgery: A Review Article
Bardia Barimani, Philippe Moisan, Carlos Santaguida, Michael Weber
International Journal of Spine Surgery May 2021, 8075; DOI: 10.14444/8075

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Therapeutic Application of Fibrinogen in Spine Surgery: A Review Article
Bardia Barimani, Philippe Moisan, Carlos Santaguida, Michael Weber
International Journal of Spine Surgery May 2021, 8075; DOI: 10.14444/8075
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  • fibrinogen
  • spine surgery
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  • hemostasis

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