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Research ArticleOther and Special Categories

Outcome of Targeted vs Empiric Antibiotic Therapy in the Treatment of Spondylodiscitis: A Retrospective Analysis of 201 Patients

Max Prost, Melanie Elisabeth Röckner, Malte Kohns Vasconcelos, Joachim Windolf and Markus Rafael Konieczny
International Journal of Spine Surgery July 2023, 8482; DOI: https://doi.org/10.14444/8482
Max Prost
1Department of Orthopedic and Trauma Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Germany
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  • For correspondence: Max.prost@med.uni-duesseldorf.de
Melanie Elisabeth Röckner
1Department of Orthopedic and Trauma Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Germany
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Malte Kohns Vasconcelos
2Institute for Medical Microbiology and Hospital Hygiene, Medical Faculty and University Hospital Düsseldorf,, Heinrich-Heine-University Düsseldorf, Germany
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Joachim Windolf
1Department of Orthopedic and Trauma Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Germany
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Markus Rafael Konieczny
1Department of Orthopedic and Trauma Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Germany
3Department of Spine Surgery, Volmarstein Orthopedic Clinic, Volmarstein, Germany
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    Figure

    Outcome of the patients according to the subgroup analyzis.

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    Table 1

    Inclusion and exclusion criteria.

     Inclusion Criteria Exclusion Criteria
    Diagnosis of spondylodiscitis with:
    • Pain at rest

    • Radiological signs for spondylodiscitis

    • Laboratory signs of infection

    Diagnosis of spondylodiscitis with:
    • Signs of sepsis or severe neurological deficit at the time of admission to our hospital

    Complete set of data, including:
    • Operative treatment

    • Antibiotic treatment

    • Microbiological results

    Incomplete set of data
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    Table 2

    Type of detected pathogen.

    Type of Pathogenn%
    Staphylococcus aureus7436.8
    Staphylococcus epidermidis2512.4
    Streptococcus spp. (excluding S pneumoniae)126.0
    Escherichia coli115.5
    Enterococcus105.0
    Mycobacteriacae52.5
    Othera2311.4
    • ↵a Includes Klebsiella pneumoniae, Parvimonas micra, Proteus vulgaris, Streptococcus pneumoniae, Pseudomonas aeruginosa, Serratia marcescens, and Salmonella enteritidis.

    • View popup
    Table 3

    Type of specimen for identification of the pathogen.

    Specimenn%
    No identification6331.3
    Blood6532.3
    Intraoperative specimen4019.9
    Percutaneous puncture199.5
    More than one115.5
    No information31.5
    Total201100.0
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International Journal of Spine Surgery: 19 (S2)
International Journal of Spine Surgery
Vol. 19, Issue S2
1 Apr 2025
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Outcome of Targeted vs Empiric Antibiotic Therapy in the Treatment of Spondylodiscitis: A Retrospective Analysis of 201 Patients
Max Prost, Melanie Elisabeth Röckner, Malte Kohns Vasconcelos, Joachim Windolf, Markus Rafael Konieczny
International Journal of Spine Surgery Jul 2023, 8482; DOI: 10.14444/8482

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Outcome of Targeted vs Empiric Antibiotic Therapy in the Treatment of Spondylodiscitis: A Retrospective Analysis of 201 Patients
Max Prost, Melanie Elisabeth Röckner, Malte Kohns Vasconcelos, Joachim Windolf, Markus Rafael Konieczny
International Journal of Spine Surgery Jul 2023, 8482; DOI: 10.14444/8482
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