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Research ArticleMinimally Invasive Surgery

Recovery of Physical Function Based on Body Mass Index Following Anterior Cervical Discectomy and Fusion

Elliot D.K. Cha, Conor P. Lynch, James M. Parrish, Nathaniel W. Jenkins, Shruthi Mohan, Cara E. Geoghegan, Caroline N. Jadczak and Kern Singh
International Journal of Spine Surgery December 2021, 15 (6) 1123-1132; DOI: https://doi.org/10.14444/8143
Elliot D.K. Cha
Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA
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Conor P. Lynch
Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA
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James M. Parrish
Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA
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Nathaniel W. Jenkins
Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA
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Shruthi Mohan
Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA
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Cara E. Geoghegan
Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA
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Caroline N. Jadczak
Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA
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Kern Singh
Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA
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    Figure

    Correlation of Delta Patient-Reported Outcomes Measurement Information System physical function (PROMIS-PF) and body mass index (BMI) at (A) 6 weeks, (B) 12 weeks, (C) 6 months, (D) 1 year, and (E) 2 years.

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    Table 1

    Baseline characteristics by BMI group.

    CharacteristicNonobese
    (N = 74)
    Obese I
    (N = 27)
    Obese II
    (N = 19)
    Obese III
    (N = 8)
    P Valuea,b
    Age, y, mean ± SD50.36 ± 10.5948.06 ± 8.0352.32 ± 10.7848.05 ± 10.350.502
    Sex, % ( n ) 0.014
     Female54.1% (40)18.5% (5)36.8% (7)37.5% (3)
     Male46.0% (34)81.5% (22)63.2% (12)62.5% (5)
    Smoking status, % (n)0.294
     Nonsmoker82.4% (61)92.6% (25)94.7% (18)75.0% (6)
     Smoker17.6% (13)7.4% (2)5.3% (1)25.0% (2)
    Insurance status, % (n)0.062
     Non-WC81.1% (60)55.6% (15)66.7% (12)62.5% (5)
     WC18.9% (14)44.4% (12)33.3% (6)37.5% (3)
    Diabetic status, % ( n ) 0.042
     Nondiabetic89.2% (66)81.5% (66)89.5% (17)50.0% (4)
     Diabetic10.8% (8)8.5% (5)10.5% (2)50.0% (4)
    Ageless CCI, mean ± SD 0.66 ± 0.92 0.59 ± 0.50 0.78 ± 1.06 1.88 ± 1.73 0.007
    Spinal diagnoses, % (n)
     Herniated nucleus pulposus83.8% (62)88.9% (24)89.5% (17)87.5% (7)0.923
     Degenerative disc disease5.4% (4)3.7% (1)5.3% (1)0.0% (0)0.907
     Foraminal stenosis12.2% (9)3.7% (1)15.8% (3)12.5% (1)0.496
    • aP value was calculated for each category using multivariate linear regression (continuous) or either χ2 analysis or Fisher’s exact test (categorical).

    • bBoldface indicates statistical significance.

    • CCI, Charlson Comorbidity Index; SD, standard deviation; WC, workers’ compensation.

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    Table 2

    Perioperative outcomes by BMI group.



    Characteristic
    Nonobese
    (N = 74)
    Obese I
    (N = 27)
    Obese II
    (N = 19)
    Obese III
    (N = 8)
    P Valuea
    Number of fusion levels, % (n)0.816
     1-Level50.0% (37)63.0% (17)57.9% (11)75.0% (6)
     2-Level36.5% (27)29.6% (8)36.8% (7)25.0% (2)
     3-Level12.2% (9)3.7% (1)5.3% (1)0.0% (0)
     4-Level1.4% (1)3.7% (1)0.0% (0)0.0% (0)
    Operative time, min, mean ± SD60.5 ± 16.255.1 ± 17.856.5 ± 16.062.3 ± 20.30.441
    Estimated blood loss, mL,mean ± SD29.5 ± 12.030.2 ± 13.032.9 ± 14.635.0 ± 21.90.578
    Length of stay, h,mean ± SD13.1 ± 12.111.4 ± 14.815.0 ± 10.611.4 ± 7.40.786
    Discharge date, % (n)0.081
     POD 074.3% (55)85.2% (23)63.2% (12)75.0% (6)
     POD 120.3% (15)11.1% (3)36.8% (7)25.0% (2)
     POD 25.4% (4)0.0% (0)0.0% (0)0.0% (0)
     POD 3+0.0% (0)3.7% (1)0.0% (0)0.0% (0)
    • aP value was calculated for each category using multivariate linear regression (continuous) or either χ2 analysis or Fisher’s exact test (categorical).

    • POD, postoperative day; SD, standard deviation.

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    Table 3

    Postoperative inpatient complications.

    Complication, % (n)Nonobese
    (N = 74)
    Obese I
    (N = 27)
    Obese II
    (N = 19)
    Severe III
    (N = 8)
    P Valuea
    Aspiration0.0% (0)0.0% (0)0.0% (0)0.0% (0)-
    Dysphagia4.1% (3)3.9% (1)0.0% (0)0.0% (0)0.773
    Urinary retention0.0% (0)0.0% (0)5.3% (1)0.0% (0)0.126
    Urinary tract infection0.0% (0)0.0% (0)0.0% (0)0.0% (0)-
    Acute renal failure0.0% (0)0.0% (0)0.0% (0)0.0% (0)-
    Postoperative anemia0.0% (0)0.0% (0)0.0% (0)0.0% (0)-
    Hematoma1.3% (1)3.9% (1)0.0% (0)0.0% (0)0.724
    Altered mental status1.3% (1)0.0% (0)0.0% (0)0.0% (0)0.868
    Venous thromboembolism0.0% (0)0.0% (0)0.0% (0)0.0% (0)-
    Pulmonary embolism0.0% (0)0.0% (0)0.0% (0)0.0% (0)-
    Pneumothorax0.0% (0)0.0% (0)0.0% (0)0.0% (0)-
    Arrhythmia0.0% (0)0.0% (0)0.0% (0)0.0% (0)-
    Pneumonia0.0% (0)0.0% (0)0.0% (0)0.0% (0)-
    Atelectasis0.0% (0)0.0% (0)0.0% (0)0.0% (0)-
    Pleural effusion0.0% (0)0.0% (0)0.0% (0)0.0% (0)-
    Fever (unknown origin)0.0% (0)0.0% (0)0.0% (0)0.0% (0)-
    Total complications 6.7% (5) 7.4% (2) 5.3% (1) 0.0% (0) 0.949
    • aP value was calculated for each category using Fisher’s exact test (categorical).

    • View popup
    Table 4

    Specific incidences of complications.

    Dysphagia: 3 patients experienced dysphagia. 2 patients suffered from mild dysphagia and were able to tolerate general diet by discharge on POD1. 1 patient experienced dysphagia and increased neck swelling on POD0 due to a hematoma. Patient underwent an incision and drainage and symptoms resolved by POD1. Patient was discharged in stable condition on POD2.
    Urinary retention: 1 patient had postoperative urinary retention on POD0 with a postvoid residual volume >500 mL. Foley was placed on POD0. Patient placed on Flomax and voided by discharge on POD1.
    Hematoma: 2 patients had a cervical hematoma on POD0 and underwent an emergent incision and drainage, which resolved symptoms. 1 patient was safely discharged to home on POD3 and another patient was discharged safely home on POD2. No other complications were noted.
    Altered mental status: 1 patient was unresponsive on POD0 and received Narcan. Neurology consult placed on POD1 with unremarkable findings. Patient discharged to home safely on POD2.
    • POD, postoperative day.

    • View popup
    Table 5

    Patient-reported outcome comparisons by BMI group.

    OutcomeMean ± SD (n) R 2 P Valuea
    Nonobese
    (N = 74)
    Obese I
    (N = 27)
    Obese II
    (N = 19)
    Obese III
    (N = 8)
    PROMIS-PF
     Preoperative40.7 ± 6.6 (74)38.6 ± 8.8 (27)38.6 ± 5.7 (19)39.4 ± 7.8 (8)0.0210.458
     6 wk42.5 ± 6.6 (53)39.6 ± 7.9 (17)39.2 ± 7.4 (15)39.3 ± 6.7 (7)0.0480.220
     12 wk45.3 ± 8.7 (47)49.7 ± 13.0 (15)40.8 ± 5.5 (13)43.9 ± 13.5 (4)0.0770.109
     6 mo47.9 ± 9.1 (41)51.7 ± 11.3 (11)41.1 ± 6.7 (11)44.5 ± 7.3 (3)0.1140.060
     1 y 50.5 ± 7.8 (35) 50.8 ± 9.5 (10) 43.0 ± 6.5 (8) 42.2 ± 6.9 (4) 0.149 0.035
     2 y 51.3 ± 7.9 (25) 45.5 ± 9.1 (10) 41.7 ± 5.0 (9) 42.5 ± 13.1 (6) 0.205 0.014
    PROMIS-PF
     6 wk Δ2.2 ± 6.5-0.93 ± 10.00.35 ± 7.50.24 ± 10.00.0270.476
     12 wk Δ 4.1 ± 7.6 10.1 ± 10.4 1.8 ± 7.3 4.3 ± 7.3 0.101 0.044
     6 mo Δ7.3 ± 6.89.8 ± 9.34.2 ± 5.37.5 ± 7.60.0530.331
     1 year Δ9.0 ± 8.010.5 ± 10.94.9 ± 5.05.0 ± 5.00.0550.388
     2 year Δ 9.9 ± 7.0 7.1 ± 8.5 2.3 ± 5.5 3.0 ± 11.7 0.156 0.048
    • aP value was calculated using linear regression (continuous) to compare each time point among subgroups.

    • BMI, body mass index; PROMIS-PF, Patient Reported Outcome Measurement Information System physical function.

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International Journal of Spine Surgery
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1 Dec 2021
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Recovery of Physical Function Based on Body Mass Index Following Anterior Cervical Discectomy and Fusion
Elliot D.K. Cha, Conor P. Lynch, James M. Parrish, Nathaniel W. Jenkins, Shruthi Mohan, Cara E. Geoghegan, Caroline N. Jadczak, Kern Singh
International Journal of Spine Surgery Dec 2021, 15 (6) 1123-1132; DOI: 10.14444/8143

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Recovery of Physical Function Based on Body Mass Index Following Anterior Cervical Discectomy and Fusion
Elliot D.K. Cha, Conor P. Lynch, James M. Parrish, Nathaniel W. Jenkins, Shruthi Mohan, Cara E. Geoghegan, Caroline N. Jadczak, Kern Singh
International Journal of Spine Surgery Dec 2021, 15 (6) 1123-1132; DOI: 10.14444/8143
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Keywords

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  • obesity
  • body mass index
  • cervical spine
  • minimally invasive
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