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Research ArticleNew Technology

Expandable Lateral Lumbar Cages With Integrated Fixation: A Viable Option for Rostral Adjacent Segment Disease

Gregory M. Malham, Carl M. Blecher, Nigel R. Munday and Ryan P. Hamer
International Journal of Spine Surgery August 2022, 16 (4) 748-759; DOI: https://doi.org/10.14444/8307
Gregory M. Malham
1 Neuroscience Institute, Epworth Hospital, 89 Bridge Road, Richmond, Melbourne, Australia
MB, ChB, FRACS
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Carl M. Blecher
2 Richmond Diagnostic Imaging, Richmond, Melbourne, Australia
MB, BS, FRANZCR, DDU
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Nigel R. Munday
1 Neuroscience Institute, Epworth Hospital, 89 Bridge Road, Richmond, Melbourne, Australia
MB, BS, MBA
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Ryan P. Hamer
3 University of Sydney, Faculty of Medicine and Health, Edward Ford Building, Fisher Road, NSW 2006, Australia
BSc, MBA
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  • Article
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  • Figure 1
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    Figure 1

    (A) L2-L3 adjacent segment disease above a previous L3-S1 posterior lumbar interbody fusion on a lateral radiograph. The expandable lateral titanium interbody cage with an integrated lateral fixation at the L2-L3 level with solid interbody fusion at 12 months noted on computed tomography. (B) Sagittal and (C) coronal views.

  • Figure 2
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    Figure 2

    Radiograph of expandable lateral titanium interbody cage with an integrated lateral fixation at the L3-L4 level with the inferior screw of the lateral plate placed above (A, B) and below (C, D) the in situ superior pedicle screw: (A, C) lateral and (B, D) anteroposterior films.

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    Table 1

    Comparative cost analysis of single-level eLLIFp, LLIF with posterior fixation, TLIF, PLIF, PLF, and ALIF.

    Procedure (Single-Level Adjacent Segment Disease/Extension of Construct)ImplantImplant ChargesTotal Implant ChargesOR Charges (Mean OR Time @ $2500/h)Inpatient Hospital Charges (Mean LOS @ $1335/d)Total Specialist (Surgeon + Anesthetist @ $19.80/unit) Medicare Charges67 Cell SaverIntraoperative Neural MonitoringMean Total Costa Cost Relativity (Using eLLIFp as Index)
    eLLIFpExpandable lateral cage with plate screws$6021; $186 × 2 (2 screws)$6393$5000 (2 h)$4005 (3 d)$2817 ($2193 + $614 [31 units])N/A$1500$19,7151
    LLIF with posterior fixationExpandable lateral cage; Polyaxial screws; Caps/blockers; Prelordosed rods$3335; $1232 × 2 (2 screws); $560 × 6 (6 caps); $410 × 2 (2 rods)$9979$7500 (3 h)$4005 (3 d)$3656 ($2923 + $733 [37 units])N/A$1500$26,6401.4
    TLIFExpandable TLIF cage; Polyaxial screws; Caps/blockers; Prelordosed rods$3335; $1232 × 2 (2 screws)b; $560 × 6 (6 caps); $410 × 2 (2 rods)$9979$7500 (3 h)$6675 (5 d)$3514 ($2663 + $851 [43 units])OptionalN/A$27,6681.4
    PLIFExpandable PLIF cage; Polyaxial screws; Caps/blockers; Prelordosed rods$2780 × 2 (2 cages); $1232 × 2 (2 screws)b; $560 × 6 (6 caps); $410 × 2 (2 rods)$12,204$7500 (3 h)$6675 (5 d)$3514 ($2663 + $851 [43 units])$500N/A$30,3931.5
    PLFPolyaxial screws; Caps/blockers; Prelordosed rods$1232 × 2 (2 screws)b; $560 × 6 (6 caps); $410 × 2 (2 rods)$6644$6250 (2.5 h)$5340 (4 d)$3232 ($2499 + $733 [37 units])$500N/A$21,9661.1
    ALIFIntegrated static cage; Screws$6021; $186 × 3 (3 screws)$6579$7500 (3 h)$6675 (5 d)$2613 ($1880 + $733 [37 units]) plus vascular surgeon: $1186$500N/A$25,0531.3
    • Abbreviations: ALIF, anterior lumbar interbody fusion; eLLIFp, expandable lateral titanium interbody cages with integrated lateral plate fixation; LLIF, lateral lumbar interbody fusion; LOS, length of stay; N/A, not applicable; OR, operating room; PLF, posterolateral instrumented fusion; PLIF, posterior lumbar interbody fusion; TLIF, transforaminal lumbar interbody fusion.

    • Note: All costs given in Australian dollars.

    • ↵a Total cost does not include charges for bone graft substitutes (which depend on the surgeon’s preference).

    • ↵b Assumes posterior fixation with 2 new screws above the construct and using the existing screws below with new caps.

    • View popup
    Table 2

    Patient and treatment characteristics.

    CharacteristicValue (N = 33)
    Age, y, mean (range)64.9 (34–82)
    Female, n (%)18 (55)
    Body mass index, kg/m2, mean (range)29.5 (20.0–38.5)
    Current smoker, n (%)4 (12)
    Previous posterior fusion level, n (%)
     L5-S1 (1-level)8 (24)
     L4-S1 (2-level)15 (46)
     L3-S1 (3-level)8 (24)
     L2-S1 (4-level)2 (6)
    Time from fusion to ASD, y, mean (range)7.8 (1–25)
    ASD pathology (35 devices), n (%)
     Degenerative spondylolisthesis12 (34)
     Foraminal stenosis10 (29)
     Canal stenosis8 (23)
     Degenerative disc disease5 (14)
    ASD level treated (35 devices)
     L1-L2, n (%)4 (11)
     L2-L3, n (%)10 (29)
     L3-L4, n (%)14 (40)
     L4-L5, n (%)7 (20)
    Psoas retraction time, min, mean (range)
     Total time30.8 (15–40)
     Time with retractor open to 22 mm14.4 (8–24)
     Time with retractor open to 25 mm13.9 (7–22)
    • Abbreviation: ASD, adjacent segment disease.

    • View popup
    Table 3

    Clinical outcome scores.

    Outcome MeasurePreop6 wk6 mo12 mo P (Preop vs 12 mo)
    Back VAS pain score7.8 ± 1.42.1 ± 0.61.3 ± 0.81.2 ± 0.8<0.0001
    Leg VAS pain score6.9 ± 2.81.8 ± 1.71.4 ± 1.21.4 ± 1.3<0.0001
    Oswestry Disability Index61.0 ± 11.539.0 ± 6.230.9 ± 16.432.2 ± 12.2<0.0001
    SF-12 physical component score30.1 ± 6.444.5 ± 7.849.0 ± 8.350.9 ± 5.4<0.0001
    SF-12 mental component score39.0 ± 7.350.1 ± 7.652.7 ± 8.155.3 ± 4.3<0.0001
    • Abbreviations: Preop, preoperative; SF-12, Short Form 12-item health survey; VAS, visual analog scale.

    • Note: Data are presented as mean ± SD.

    • View popup
    Table 4

    Lordosis and posterior disc height on computed tomographic images.

    TimeSegmental Lordosis, °Lumbar Lordosis, °Posterior Disc Height, mm
    Preop8.2 ± 4.141.0 ± 11.23.2 ± 1.6
    Postopa 10.6 ± 2.943.1 ± 8.46.0 ± 1.7
    Fusionb 10.4 ± 4.143.2 ± 11.05.9 ± 1.5
    P (preop vs postop)0.00780.3921<0.0001
    P (preop vs fusion)0.03300.4238<0.0001
    P (postop vs fusion)0.81980.96700.8008
    • Abbreviations: postop, postoperative; preop, preoperative.

    • Note: Data are mean ± SD.

    • ↵a At 6 wk postoperatively.

    • ↵b At the time of fusion (6 or 12 mo postoperatively).

    • View popup
    Table 5

    Fusion rates on computed tomography images at 6 and 12 mo postoperatively.

    Time% Solid Interbody Fusion (n Fused/n Total)
    6 mo53 (18/34)
    12 mo94 (32/34)
    • Abbreviation: n, number of cages.

    • View popup
    Table 6

    Minor and major complications.

    ComplicationNumber
    Minor
     Anterior thigh sensory change1
     Anterior thigh pain1
     Atelectasis0
     Ileus0
     Superficial wound infection0
     Hematoma0
     Incisional hernia0
     Total 2
    Major
     Radiculopathy (motor deficit)1
     Femoral neuropathy0
     Pneumothorax0
     Deep wound infection0
     Bowel injury0
     Major vascular injury0
     Subsidence0
     Cage migration0
     Screw loosening or fracture0
     Vertebral fracture0
     Revision surgery0
     Total 1
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International Journal of Spine Surgery
Vol. 16, Issue 4
1 Aug 2022
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Expandable Lateral Lumbar Cages With Integrated Fixation: A Viable Option for Rostral Adjacent Segment Disease
Gregory M. Malham, Carl M. Blecher, Nigel R. Munday, Ryan P. Hamer
International Journal of Spine Surgery Aug 2022, 16 (4) 748-759; DOI: 10.14444/8307

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Expandable Lateral Lumbar Cages With Integrated Fixation: A Viable Option for Rostral Adjacent Segment Disease
Gregory M. Malham, Carl M. Blecher, Nigel R. Munday, Ryan P. Hamer
International Journal of Spine Surgery Aug 2022, 16 (4) 748-759; DOI: 10.14444/8307
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Keywords

  • adjacent segment disease
  • expandable lateral lumbar cages
  • posterior lumbar fusion
  • cost analysis

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