Article Figures & Data
Figures
- Figure 1
Flowchart of the search strategy and selection process for this article.
- Figure 2
Different techniques are available to investigate mechanotransduction pathways, including atomic force microscopy, microneedle manipulation, micropipette aspiration, acoustic tweezers, magnetic tweezers, twisting cytometry, and a uniaxial stretcher (left to right). Adapted from Mohammed et al3 in accordance with Frontiers Creative Commons license. Copyright 2019 Mohammed, Versaevel, Bruyère, Alaimo, Luciano, Vercruysse, Procès, and Gabriele. Published by Frontiers Media.
- Figure 3
Illustration of force mechanotransduction (green) and cell-matrix signaling (purple) in a 3D fibrous matrix where a cell grows. Eukaryotic cells respond to external forces by modifying their migration, shape, stiffness, spreading, alignment, or adhesion behaviors. The extracellular matrix (ECM) presents several cues to cells, such as confinement, topography, rigidity, and biochemistry. Both types of mechanotransduction are facilitated by focal adhesion, which recruits transmembrane integrins. The nucleus converts mechanical signals (small arrows) into biological responses. Adapted from Mohammed et al3 in accordance with Frontiers Creative Commons license. Copyright 2019 Mohammed, Versaevel, Bruyère, Alaimo, Luciano, Vercruysse, Procès and Gabriele. Published by Frontiers Media.
- Figure 4
A diagrammatic representation of the primary cycles underlying cell and tissue shaping. In most instances, activation of the motility process is initiated by intrinsic cell signals involving G proteins, kinases, and actomyosins. These structures alter cell morphology or stimulate neighboring cells to allow testing of the mechanical environment, consequently producing cellular responses that maintain cell morphology. Adapted from Wolfenson et al with permission from Annual Reviews. Copyright 2019 Wolfenson, Sheetz, Yang. Published by Annual Reviews.
- Figure 5
The diamond model of bone healing interaction.25,27
- Figure 6
This diagram highlights the role of biologics, bulk modifications, and surface modifications in collectively improving the biocompatibility of metallic implants. Adapted from Bandyopadhyay et al28 with permission from Elsevier. Copyright 2022 Bandyopadhyay, Mitra, Goodman, Kumar, and Bose. Published by Elsevier Ltd.
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