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Research ArticleMinimally Invasive Surgery

Multilevel Minimally Invasive Lumbar Decompression: Clinical Efficacy and Durability to 2 Years

Ryan Khanna, Hani Malone, Kavantissa M. Keppetipola, Harel Deutsch, Richard G. Fessler, Ricardo B. Fontes and John E. O'Toole
International Journal of Spine Surgery August 2021, 15 (4) 795-802; DOI: https://doi.org/10.14444/8102
Ryan Khanna
1Department of Neurosurgery, Rush University Medical Center, Chicago, Illinois
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Hani Malone
2Department of Neurosurgery, Scripps Clinic, La Jolla, California
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Kavantissa M. Keppetipola
1Department of Neurosurgery, Rush University Medical Center, Chicago, Illinois
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Harel Deutsch
1Department of Neurosurgery, Rush University Medical Center, Chicago, Illinois
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Richard G. Fessler
1Department of Neurosurgery, Rush University Medical Center, Chicago, Illinois
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Ricardo B. Fontes
1Department of Neurosurgery, Rush University Medical Center, Chicago, Illinois
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John E. O'Toole
1Department of Neurosurgery, Rush University Medical Center, Chicago, Illinois
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ABSTRACT

Background: The clinical efficacy of single-level minimally invasive lumbar decompression and/or microdiscectomy is well established, with improved postoperative functional outcome and pain scores. However, there is a paucity of clinical data supporting the use of minimally invasive (MIS) techniques in a single operation to address pathology at multiple lumbar levels, and this study attempts to address this issue.

Methods: A retrospective review of prospectively collected data from patients with symptomatic lumbar stenosis and/or disc herniations who underwent multilevel minimally invasive decompression or microdiscectomy from November 2014 to February 2018 was conducted at a single academic medical center. Patient-reported outcome measures (PROMs), including the Oswestry Disability Index (ODI), visual analog scale (VAS) for back and leg pain, 12-Item Short Form Health Survey (SF-12) Physical Component Summary Score (PCS) and Mental Component Summary Score (MCS), and Scoliosis Research Society survey (SRS-30), were prospectively collected before surgery and at 3 months, 6 months, 1 year, and 2 years postoperatively.

Results: During the study period, 92 patients received multilevel (≥2 level) MIS lumbar decompression and/or discectomy (69 two level, 21 three level, 2 four level). The mean age at surgery was 69.7 years, and 23 (25%) patients were women. Patient-reported outcomes were significantly improved both in the short and long term except for the SF-12 MCS. Average improvement from baseline was (at 3 months and 2 years, respectively): VAS back, −3.9 and −2.8; VAS leg, −3.6 and −2.6; ODI, −13 and −14.6; SF-12 MCS, 2.8 and −0.3; SF-12 PCS, 6.9 and 10.1; and SRS-30, 0.57 and 0.55. Minimal clinically important difference for the study population was reached for every PROM except SF-12 MCS. Surgical complications occurred in 16 patients (17.4%), and 8 patients (8.6%) required postoperative fusions within 2 years.

Conclusion: The use of MIS techniques to perform lumbar decompression and/or discectomy at multiple levels was found to be both clinically effective and durable. Fusion rates remained low 2 years after the index surgery and were consistent with literature data for open procedures.

Level of Evidence: 2.

  • MIS
  • minimally invasive
  • decompression
  • discectomy
  • multilevel
  • laminectomy
  • PROM

INTRODUCTION

Lumbar spinal stenosis is a degenerative condition defined as narrowing of the central spinal canal, the vertebral foramina, and/or the lateral recesses, causing impingement on nearby neurologic structures. This condition largely affects the elderly and can cause a variety of debilitating symptoms, including back and radicular leg pain and neurogenic claudication. Similar symptoms can also occur due to vertebral disc herniation causing impingement on neurologic structures. In the absence of progressive neurologic deficit or intractable pain, first-line treatment is nonoperative, consisting of physical therapy and pharmacotherapy (analgesics, steroids).1 When nonoperative measures fail to provide relief, surgical decompression of the neural elements has been shown to significantly alleviate symptoms.2–7

Surgical techniques vary, but traditional “open” lumbar decompression procedures involve subperiosteal dissection of the paraspinal musculature to facilitate laminectomy and/or laminotomy. The adaptation of minimally invasive spine (MIS) techniques for single-level surgery allowed for equally efficacious lumbar decompressions with the goal of decreasing postoperative pain, muscle disruption, blood loss, and length of hospitalization.5,8,9 Several studies have reported that single-level MIS decompression of lumbar compressive pathology leads to improved postoperative functional outcome and pain scores.9,10 However, there is a paucity of clinical data to support the use of MIS decompression and/or discectomy to address pathology at multiple lumbar levels during a single operation. This study aims to investigate whether multilevel MIS decompression and/or discectomy leads to significant and durable improvements in postoperative function and pain scores.

METHODS

Patient Population and Surgical Technique

Following institutional review board approval, information for patients operated upon by 4 neurosurgeons at a large academic tertiary center were collected for a retrospective review of prospectively collected data from 2014–2018. All patients aged 45 years or older with symptomatic lumbar degenerative stenosis who underwent a posterior MIS decompression (laminectomy, foraminotomy, and/or discectomy) at 2 or more levels during the study period were included. Nondegenerative pathology (trauma, infection, neoplasms) or emergent procedures (precluding compilation of outpatient preoperative data) were not included.

Decompressive Procedure

Experienced neurosurgeons performed MIS decompressions, discectomies, and foraminotomies for patients with lumbar stenosis at ≥2 levels.11,12 The technique of MIS laminectomy used was a modification of the technique of unilateral approach for bilateral decompression described by Guiot, Khoo, and Fessler12 in 2002, using ×3.5 loupe magnification or the operative microscope. Under fluoroscopy, the desired level was identified and a paramedian skin incision made. Sequential dilators were used to place a tubular working channel 18–22 mm in diameter over the ipsilateral target lamina. Soft tissue was cleared, and a high-speed drill and/or Kerrison rongeur was used to perform an ipsilateral laminectomy while preserving the pars and cranial segment of the lamina. The cranial limit of the decompression was the insertion of the ligamentum flavum. For the contralateral part of the decompression, the flavum was maintained in place, the tube was aimed contralaterally, and a sublaminar or “over the top” laminectomy, medial facetectomy, and foraminotomy was performed. Resection of the ligamentum flavum and the contralateral medial facetectomy were completed using a Kerrison rongeur reaching from the tip of the superior articular process to the middle of the caudal pedicle. The contralateral disc and pedicle were visualized, and complete decompression of the contralateral traversing nerve root was confirmed. Sometimes, the ipsilateral medial facetectomy and foraminotomy was also finalized after the contralateral work was completed. In the case of a discectomy procedure, the contralateral work was not always necessary and after removal of the ligamentum flavum, the nerve root was retracted medially to expose the disc, in the usual fashion.13 This process was repeated at each level (≥2) of the patient's pathology. The same incision could be used for immediately adjacent cranial and caudal levels, or alternating sides of the approach for different levels could be used to allow 2 surgeons to operate simultaneously if so desired.14 In all procedures used, the midline dorsal osseous and ligamentous structures were preserved.

Data Collection and Analysis

Demographic and surgical data were extracted from the electronic medical record. The incidence of additional lumbar surgical procedures including fusions after the index operation was determined, as were the reasons for these additional procedures and the presence of preoperative spondylolisthesis or scoliosis. Patient-reported outcome measures (PROMs) were digitally collected and tracked on a HIPAA-compliant online database (OBERD, Universal Research Solutions LLC, Columbia, MO). Preoperatively and at each follow-up clinic visit (scheduled at 3 months, 6 months, 1 year, and 2 years postoperatively), patients prospectively completed multiple questionnaires: Numeric Rating Scale for Back and Leg (NRS-B/L), Oswestry Disability Index (ODI), Mental and Physical component scores of the 12-item Short Form Health Survey (SF-12 MCS and PCS), and the Scoliosis Research Society survey (SRS-30).4–7

Statistical Methods

PROMs at each time were analyzed using the Student t test and were compared with preoperative baseline, at a significance level of .05.

RESULTS

Patient Characteristics

A total of 104 study-eligible patients underwent multilevel (≥2 levels) MIS lumbar decompression, discectomy, and/or foraminotomy from 2014–2018 (Table 1). Twelve patients were excluded due to a lack of adequate PROMs preoperatively or postoperatively. A total of 69 patients had 2-level procedures, 21 had 3-level procedures, and two had 4-level procedures. Mean age at surgery was 69.7 ± 9 years, and 25% of the patients were women. The mean operative time was 117 ± 63 minutes and mean estimated blood loss was 79 mL. Two-level surgeries lasted on average 106 minutes, 3-level surgeries lasted on average 143.5 minutes, and 4-level surgeries lasted on average 195 minutes. For 2-level surgeries, 14 out of 69 (20.3%) resulted in complications; for 3-level surgeries, 2 out of 21 (9.5%) resulted in complications; and for 4-level surgeries, there were no complications in 2 patients. Fifteen cases (16%) were complicated by a durotomy. Most of these (11 cases) were treated by buttressing the durotomy with gelatin sponge and dural sealant. Four patients underwent primary suture repair during the initial surgery. When broken down per level, the durotomy rate was 7.2%. No reoperations were necessary for pseudomeningocele, although 1 case was managed with a blood patch and lumbar drainage at 2 months postoperatively. The single early reoperation (1.1%) in our series was due to an epidural hematoma that required a return to the operating room on postoperative day 3. At the 3-month follow-up, 95% of patients had completed their online PROM forms. This number decreased to 68%, 50%, and 24% at 6, 12, and 24 months, respectively. We had clinical follow-up through electronic medical record for additional operations (no PROMs) for 100% of patients at 3 months, 95% at 6 months, 86% at 1 year, and 61% at 2 years.

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Table 1

Patient demographic and surgical data.

Patient-Reported Outcome Measures

The average of each preoperative PROM is reported in Table 2, as is the average postoperative change from baseline at each time point. To establish the clinical significance of these values, the minimum clinically importance difference (MCID) was also reported.15,16 All postoperative values were statistically significantly improved compared with preoperative values (P < .001) except the 3-month SF-12 MCS (P = .016), 6-month SF-12 MCS (P = .904), 1-year SF-12 MCS (P = .326), and 2-year SF-12 MCS (P = .882; Table 2 and Figure 1). In addition, Table 3 details the percentage of patients who reached MCID at each postoperative time point.

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Table 2

Baseline PROM and postoperative change, mean ± standard deviation.

Figure 1
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Figure 1

Comparison of change of PROM from preoperative baseline at 3 months, 6 months, 1 year, and 2 years postoperatively from index decompression: (a) NRS-B, (b) NRS-L, (c) ODI, (d) SF12-M, (e) SF12-P, (f) SRS-30). Abbreviations: M, Mental Component Score; NRS-B, Numeric Rating Scale–Back; NRS-L, Numeric Rating Scale–Leg; ODI, Oswestry Disability Index; P, Physical Component Score; SF-12, 12-item Short Form Health Survey; SRS-30, Scoliosis Research Society survey.

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Table 3

Percentage of patients who met MCID at each time point.

Postoperative Fusions

At the 2-year follow-up, 8 of our 92 patients (8.7%) went on to require a lumbar fusion at an average of 485 days postoperatively. Table 4 lists the initial surgery, the follow-up fusion, the postoperative day from the index operation, preoperatively spondylolisthesis or scoliosis, and the reason for the follow-up fusion. In Figure 2, we detail the preoperative, postoperative but prefusion, and postfusion imaging of patient 7 (64-year-old man) as an example of a patient who ultimately required lumbar fusion. In this case, adequate decompression was achieved following L3-L5 laminectomy; however, the patient developed a grade I spondylolisthesis and ultimately required L4-L5 transforaminal lumbar interbody fusion.

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Table 4

Secondary surgery data.

Figure 2
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Figure 2

Example of patient who ultimately required lumbar fusion after original decompression. (a) Preoperative sagittal and axial MRI at L4-5 prior to L3-5 MIS laminectomy. (b) Postoperative sagittal and axial MRI at L4-L5 after L3-L5 MIS laminectomy. (c) Upright XR demonstrating postoperative grade I spondylolisthesis at L4-L5. (d) Postoperative upright XR after L4-L5 TLIF. TLIF, transforaminal lumbar interbody fusion; XR, x-ray.

DISCUSSION

Symptomatic lumbar stenosis is one of the few neurosurgical pathologies for which there is level 1 evidence of surgical treatment being superior to prolonged nonoperative management for up to 8 years after the index operation.6,17 The Spine Patient Outcomes Research Trial (SPORT) included patients with both single-level and multilevel symptomatic compression, but patient outcomes were not analyzed in terms of number of operated levels. There have been a few publications suggesting that patients undergoing multilevel decompressions for stenosis have worse outcomes than those undergoing single-level surgery. Ulrich et al18 have recently reported similar long-term PROM outcomes but significantly higher rates of perioperative complications in patients undergoing multilevel decompressions. Adilay and Guclu19 reported worse outcome scores for patients undergoing multilevel decompressions, in addition to higher perioperative complications. These findings are likely a reflection of the increased magnitude of the surgery and possibly greater age or comorbidities in those patients who require multilevel decompression. In that regard, the use of MIS techniques are appealing when developing surgical treatment plans for such patient populations. We have attempted to demonstrate that improvement afforded by multilevel decompression when using MIS techniques is durable and, and similarly durable to open techniques without increased need for reoperations.

There is significant evidence that MIS techniques applied to single-level lumbar pathology result in decreased estimated blood loss, tissue injury, and fewer perioperative complications.20,21 The questions surrounding MIS applicability to multilevel stenosis involve, first, its ability to effectively decompress the canal (ie, short-term improvement) but also whether that improvement is durable without development of structural complications sooner than with open procedures (ie, spondylolisthesis, scoliosis, or re-stenosis). In this study, we were able to prospectively collect 2-year PROM for patients undergoing minimally invasive decompressions for lumbar stenosis at multiple levels. Short-term results of the effectiveness of MIS decompression for stenosis were redemonstrated, but our study population also demonstrated sustained and statistically significant improvement beyond MCID in all PROM categories except for the SF-12 MCS at the 3-month, 6-month, 1-year, and 2-year time points. Complications were relatively few including a 16.3% durotomy rate per patient and 1 patient requiring evacuation of a postoperative hematoma. This complication pattern is consistent with prior studies for both 1-level pathology and open surgical approaches.19,22–24 As shown by the SPORT data, multilevel cases have higher durotomy rates due to the larger extent of exposed dura.25 Similarly to most minimally invasive studies, there were no surgical site infections.26,27 Durotomies were mostly managed with a blood-soaked gelatin sponge buttress and dural sealant, rarely requiring direct suturing (only 4 patients), and overnight bedrest. No reoperations were necessary for durotomy, although 1 patient required a blood patch with lumbar drain for repair of pseudomeningocele 2 months postoperatively.

Beyond short-term efficacy and safety, long-term durability is a concern regarding multilevel MIS decompression. Historically, the development of postoperative spondylolisthesis is the classical postoperative sign of structural progression and has even been termed iatrogenic. However, the spondylolisthesis itself may not completely capture all the indications for a patient requiring a fusion following a laminectomy, and only rarely can a pars fracture be identified in those patients who develop the spondylolisthesis. Other signs of progressive structural compromise include worsening of a coronal deformity leading to foraminal stenosis, back pain consequent to disc degeneration, or persistence or worsening of foraminal stenosis requiring a full facetectomy for foraminal decompression, for example. Several anatomical and surgical factors are thought to influence the development of structural progression: Soft tissue disruption, extent of facetectomy, number of levels operated on, sagittal balance, and disc height are the most frequently quoted.28 In addition, lumbar decompression is frequently offered as a “first-tier” operation to patients with varying degrees of preexisting foraminal stenosis, spondylolisthesis, and scoliosis in lieu of a more invasive, rigid fusion. In the SPORT trial for stenosis, reoperation rates at 2 years for the observational and randomized cohorts were 8% and 6%, respectively.6 At 8 years, these numbers had increased to 17% and 19%, respectively.17 The reported rate of reoperation after laminectomy in the literature from 1976–2015 varies from 1.6%–32%, significantly affected by multiple factors such as historical period, geographical location, and attitude regarding recurrent low back symptoms following a decompression. In another modern series, Ramhmdani et al28 reported a 9.5% rate of fusion following a 1- to 4-level open laminectomy, at an average of 19 months following the index operation.

Minimally invasive techniques, particularly when using unilateral access for bilateral decompression (aka “over-the-top” decompression), offer an appealing alternative by minimizing some of the proposed mechanisms of structural progression such as ligament and muscle damage and extent of facetectomy. In our series, 9% of our patients required subsequent fusion at an average of 16 months after decompression, which is consistent with published data. It should be noted that 50% of these patients had preexisting spondylolisthesis or scoliosis, an element that is absent from most multilevel laminectomy series. In these cases, each of the patients were counseled that a fusion may be necessary, but in conjunction with the surgeon, patients made the decision to undergo a smaller procedure first to see if it alleviated their symptoms.

To our knowledge, this is the first study that demonstrates durable clinical effectiveness of multilevel MIS lumbar decompression out to 2 years postoperatively, consistent with 1-level data and comparing favorably with open multilevel series.29 There are several limitations to this study. Despite effort to prospectively collect all clinical data, lost to follow-up rates were 14.1% (13/92) of patients at 1 year and 39.1% (36/92) at 2 years. The results described here obviously might be different from results if these patients sought care elsewhere for poor results of initial decompression, but they could also be interpreted as the patients being symptom-free and following up locally. In our experience the 1-year clinical follow-up rate of 85.9% is quite high for a decompression-only study in a location without a clinically dominant hospital system and long travel times to a tertiary academic institution. External validity of these results may also be an issue because this study was performed at an academic institution where all participating surgeons were proficient with MIS techniques and had more than 5 years of experience. Over 90% of lumbar decompressions at our institution are, in fact, performed MIS, and given the learning curve, these results may not be immediately generalizable.30 Finally, longer-term follow-up is necessary as shown in the SPORT trial, in which the reoperation rates continued to steadily rise up to 8 years after surgery.

CONCLUSION

This study provides evidence that the use of MIS surgical techniques to treat multilevel lumbar stenosis is clinically effective and durable up to 2 years postoperatively with low rates of complications and reoperations. These data may support the creation of a randomized prospective trial to provide a more robust evidence base comparing MIS with open techniques in multilevel decompressive procedures in the lumbar spine. MIS is quickly progressing to becoming not simply an established surgical method for lumbar stenosis but perhaps the preferred surgical technique pending additional investigation.

Footnotes

  • Disclosures and COI: No financial support was required for this study. The authors report no conflicts of interest.

  • This manuscript is generously published free of charge by ISASS, the International Society for the Advancement of Spine Surgery. Copyright © 2021 ISASS

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International Journal of Spine Surgery
Vol. 15, Issue 4
1 Aug 2021
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Multilevel Minimally Invasive Lumbar Decompression: Clinical Efficacy and Durability to 2 Years
Ryan Khanna, Hani Malone, Kavantissa M. Keppetipola, Harel Deutsch, Richard G. Fessler, Ricardo B. Fontes, John E. O'Toole
International Journal of Spine Surgery Aug 2021, 15 (4) 795-802; DOI: 10.14444/8102

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Multilevel Minimally Invasive Lumbar Decompression: Clinical Efficacy and Durability to 2 Years
Ryan Khanna, Hani Malone, Kavantissa M. Keppetipola, Harel Deutsch, Richard G. Fessler, Ricardo B. Fontes, John E. O'Toole
International Journal of Spine Surgery Aug 2021, 15 (4) 795-802; DOI: 10.14444/8102
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Keywords

  • MIS
  • minimally invasive
  • decompression
  • discectomy
  • multilevel
  • laminectomy
  • PROM

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